Drug Treatment of Peptic Ulcer Disease
ثبت نشده
چکیده
Peptic ulcer disease is a widely prevalent upper gastrointestinal disorder worldwide. Gastric hypersecretion is recognized as the prime underlying cause of this disease. Earlier approaches towards alleviation of this disease have primarily focussed on symptomatic treatment of gastric hypersecretion with anti-secretory agents. Histamine H2 receptor antagonists represented the first successful mechanistic intervention with acid hypersecretion and the prototypic drug cimetidine earned the title of ‘first blockbuster drug’ due to its stupendous sales. Cimetidine, ranitidine and famotidine remained as first-line therapy for peptic ulcer disease for a very long time. H2 receptor antagonists had some limitations such as, ineffective daytime acid control, development of tolerance during therapy and acid rebound. Identification of the proton pump, H+/K + -ATPase, as final source of gastric acid secretion led to development of another novel class of antisecretory agents, termed as proton pump inhibitors (PPIs). These agents gave more potent and reproducible acid suppression compared to the H2 receptor antagonists and soon became first line drugs Bali A* University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, India *Corresponding author: Alka Bali, Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh,160014, India, Tel: 91-172-2541142; Fax: 91-172-541142; E-mail: alka.bali@rediffmail. com Published Date: April 16, 2016
منابع مشابه
Evaluation of frequency polymorphism Interleukin 1B gene in patients with peptic ulcer and chronic gastritis
Introduction: Helicobacter pylori is the main cause of chronic inflammation and peptic ulcer. More than half of the world population is afflicted with Helicobacter, while only 20% of people show the clinical symptoms of the disease. Genes encoding the cytokines interleukin (IL)-1B play a key role in the inflammatory responses of gastric mucus. This study aims to analyze polymorphism in the IL-1...
متن کاملSurvey of knowledge,Attitude and practice among general practitioners and internists on helicobacter pylori in peptic ulcer disease in Kerman
physicians awareness about Helicobacter pylori association with peptic ulcer disease (PUD)has changed the natural course of this prolonged disease.Eradication of this organism has declined the incidence of complications and recurrence of PUD significantly in recent years.the aim of this cross sectional study was to evaluate the level of knowledge,attitude and practice (KAP) of general practitio...
متن کاملDrug-induced peptic ulcer disease
Journal of the Malta College of Pharmacy Practice 15 Introduction Following the discovery of the association of peptic ulcer disease with Helicobacter pylori infection there has been a decline in the prevalence of uncomplicated peptic ulcer disease. In contrast, a striking rise in admissions for ulcer haemorrhage and perforation among elderly people is now being observed. This rise has been att...
متن کاملFloating Drug Delivery Systems for Eradication of Helicobacter pylori in Treatment of Peptic Ulcer Disease
متن کامل
Helicobacter pylori infection and perforated peptic ulcer prevalence of the infection and role of antimicrobial treatment.
Although the role of Helicobacter pylori infection on noncomplicated peptic ulcer disease has been definitively established, the precise relationship between the organism and complicated ulcer has hardly been studied. The mean prevalence of H. pylori infection in patients with perforated peptic ulcer is of only about 65-70%, which contrasts with the almost 90-100% figure reported in noncomplica...
متن کاملAcase of Retroperitoneal Castlema\'s Disease with Perforated Peptic Ulcer
SUMMARY Castleman's disease is a rare condition. In its classic form Castlema's is a solitary lesion, two third of patients have tumour like mass in the mediastinum. Extrathoracic sites also could be affected including those where lymph nodes normaly occur ancl rarely tissues where lymph nodes are not found. More recently there have been several reports of patients with multi centeric involvem...
متن کامل